PhD Student (gn*) Immunology

To meet our high standards every day, we are looking forward to your scientific support at the Institute for Experimental Pathology - ideally with you on board! THE PROJECT: In a project funded by the IZKF (Interdisciplinary Centre for Clinical Research Münster), the newly established research group of Dr. Mariano Malamud is investigating the role of inhibitory receptors in the regulation of chronic inflammatory conditions. Inhibitory receptors are germline-encoded innate receptors that play a central role in maintaining immune homeostasis. Their loss or mutation is often associated with unchecked inflammation and destructive autoimmunity. This PhD project will focus on unraveling the specific role of a newly described inhibitory receptor that regulates cellular responses (Malamud et al., Nature 2024) in obesity and its associated metabolic disorders, with particular emphasis on atherosclerosis. The project builds on and complements the institute's expertise, led by Prof. Oliver Soehnlein, in understanding how neutrophils drive chronic sterile inflammation (Soehnlein et al., Nat Rev Immunol, 2017; Silvestre-Roig et al., Nature, 2019; Soehnlein & Libby, Nat Rev Drug Discov, 2021).

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