- Characterization of modulators and functional analysis of Kv7 channels and/or proteases
Working with transfection of heteromeric channel constructs; different electrophysiology techniques in oocytes and cells, stem cell derived 2D-cell cultures; high resolution microscopy; 3D modeling protein of individual electrical active cells and cells in a tissue like conformation
Part of Research...
Vollzeitstellen: Student Jobs von Universitätsklinikum Münster
- Generate collagenase-sensitive probes whose cleavage site depends on native triple-helical conformation of collagen
Equip these collagenase-sensitive probes with FRET (Förster resonance energy transfer)- and FLIM (fluorescence life time microscopy)-capable molecular moieties, which enable fluorescence-based real-time monitoring of their cleavage
Determine characteristic features of the probes, such as thermal stability of the triple-helical...